Publications

Clinical and Translational Psychiatric Genetics

  1. Besterman AD, Adams DJ, Wong NR, Schneider BN, Mehta S, DiStefano C, Wilson RC, Martinez-Agosto JA, Jeste SS. Genomics-informed Neuropsychiatric Care for Neurodevelopmental Disorders: Results from A Multidisciplinary Clinic. Genetics in Medicine In Press
  2. Mortazavi M, Batalov S, Lenberg J, Blucher C, Omorodion A, Helbling D, Van Der Kraan L, Bezares-Orin Z, Ramalingam A, Bainbridge MN, Sebat J, Besterman AD. Long-Read Genome Sequencing in Clinical Psychiatry: RFX3 Haploinsufficiency in a Hospitalized Adolescent with Autism, Intellectual Disability, and Behavioral Decompensation. American Journal of Psychiatry. In Press.
  3. Wong NR, Klomhaus AM, Adams, DJ, Schneider BN, DiStefano C, Wilson RB, Martinez-Agosto JA, Jeste SS, Besterman AD. (2024) Clinical Factors Associated with Genetic Diagnosis in Suspected Neurogenetic Disorders in a Tertiary Care Clinic . Genetics in Medicine. 2024 Oct 10:101252. doi: 10.1016/j.gim.2024.101252. Epub ahead of print. PMID: 39395029
  4. Besterman AD. (2023) A Genetics-Guided Approach to the Clinical Management of Schizophrenia. Schizophrenia Research. S0920-9964(23)00353-5. PMID: 37813777
  5. Simon JH, Hyde C, Wilson R, Distefano C, Besterman AD, Jeste SS (2022) The Diagnostic Journey of Genetically Defined Neurodevelopmental Disorders. Journal of Neurodevelopmental Disorders. 14(1): 27. PMCID: PMC9059413
  6. Moore S, Amatya DN, Chu MM, Besterman AD. (2022) Catatonia in Autism and Other Neurodevelopmental Disabilities: A State-of-the-art Review. NPJ Mental Health Research. 1(12). PMCID: PMC10955936
  7. Besterman AD and Jeste SS. (2021) Dual Orexin Receptor Antagonists for Insomnia in Youth with Neurodevelopmental Disorders: A Case Series and Review. European Child & Adolescent Psychiatry. PMID: 34611728
  8. Besterman AD, Sadik J, Enenbach MJ, Quintero-Rivera F, DeAntonio M, Martinez-Agosto JM. (2020) The Feasibility and Outcomes of Genetic Testing for Autism and Neurodevelopmental Disorders on an Inpatient Child and Adolescent Psychiatry Service. Autism Research. 13(9):1450-1464. PMID: 32662193
  9. Hirschtritt ME, Besterman AD, Ross DA (2016). Psychiatric Pharmacogenomics: How Close Are We? Biological Psychiatry. 80(8): e63-e65. PMCID: PMC5371713
  10. Law AJ, Wang Y, Sei Y, O'Donnell P, Piantadosi P, Papaleo F, Straub RE, Huang W, Thomas CJ, Vakkalanka R, Besterman AD, Lipska BK, Hyde TM, Harrison PJ, Kleinman JE, Weinberger DR (2012). Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy. Proceedings of the National Academy of Sciences 109(30):12165-70. PMCID: PMC3409795

Rare Disease Research

  1. Tan S, Zhang Q, Zhan R, Luo S, Han Y, Yu B, Muss C, Pingault V, Marlin S, Delahay A, Peters S, Perne C, Kreiß M, Spataro N, Trujillo-Quintero JP, Racine C, Tran-Mau-Them F, Phornphutkul C, Besterman AD et al. Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay. Molecular Psychiatry. doi: 10.1038/s41380-024-02806-z. Epub ahead of print. PMID: 39472663.
  2. Barbour K, Bainbridge MN, Wigby K, Besterman AD, Chuang NA, Tobin L, Del Campo M, Lenberg J, Bird LM, Friedman J. The Face and Features of RNU4-2: A New, Common, Recognizable, Yet Hidden Neurodevelopmental Disorder. Pediatric Neurology.Epub Sep 22, 2024.
  3. Nguyen MG, Tronick L, Modirian F, Mardach R, Besterman AD. (2022) Neuropsychiatric and Neurodevelopmental Manifestations of Cobalamin C Disease: A Case Report and Review of the Literature. Cold Spring Harbor Molecular Case Studies. 8(2): a006179. PMCID: PMC8958916
  4. Besterman AD, Althoff T, Elffereich P, Gutierrez-Meija I, Sadik J, Bernstein JA, van Ierland Y, Kattentidt‐Mouravieva AA, Nellist M, Abramson J, Martinez-Agosto JA. (2021) Functional and Structural Analyses of Novel Smith-Kingsmore Syndrome-Associated MTOR Variants Reveal Potential New Mechanisms and Predictors of Pathogenicity. PLOS Genetics. 17(7): e1009651. PMCID: PMC8279410
  5. Besterman AD, Hendren RL (2015). Psychopharmacological management of problem behaviors in Mowat-Wilson Syndrome. Journal of Child and Adolescent Psychopharmacology. 25(8): 656–657. PMCID: PMC4615772
  6. Besterman AD, Wilke SA, Mulligan TE, Allison SC, Hagerman R, Seritan AL, Bourgeois JA (2014). Towards an understanding of neuropsychiatric manifestations in fragile X premutation carriers. Future Neurology 9(2): 227-39. PMCID: PMC4086747

Immunopsychiatry

  1. Tyagi R, Yang J, Blucher C, Besterman AD*, Bartley C*. False positive detection of paraneoplastic antigen Ma2 (PNMA2) on the Human Proteome microarray. Neurology: Neuroimmunology & Neuroinflammation. 2024;10(5). https://doi.org/10.1212/NXI.0000000000200145

Psychiatric Genetics Education

  1. Besterman AD, Alnor MA, Castaño M, DeLisi LE, Grice DE, Lohoff FW, Middeldorp CM, Müller DJ, Quattrone D, Nurnberger J Jr, Nurmi EL, Ross DA, Soda T, Schulze TG, Trost B, Vilella E, Yap CX, Zai G, Moreno-De-Luca D. Psychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals. American Journal of Psychiatry. In Press.
  2. Besterman AD, ISPG Education Committee. (2023) Genetics for mental health clinicians: a call for a globally accessible and equitable psychiatric genetics education. World Psychiatry. 23(1):161-163. PMID: 38214631
  3. Hwong AR, Morgan S, Young C, Besterman AD, Jacob M, Williams J, Reus VI, Mathews C, Hung E, Voglmaier S. (2021) Development and Implementation of the Role of a Chief Resident for Research in a Psychiatry Residency Training Program. Advances in Medical Education. 12:1231-1236. PMCID: PMC8549966
  4. Besterman AD, Moreno-de-Luca D, Nurnberger J. (2019) 21st century genetics in Psychiatry Residency Training: How do we get there? JAMA Psychiatry. 76(1): e1-e2. PMCID: PMC8404972
  5. Nurnberger J, Austin J, Berrettini W, Besterman AD et al. (2018) What Should a Psychiatrist Know about Genetics? Review and Recommendations from the Education Taskforce of the International Society of Psychiatric Genetics. Journal of Clinical Psychiatry. 80(1): e1-e6. PMCID: PMC6480395
  6. Besterman AD, Williams JK, Reus VI, Pato MT, Voglmaier SM, Mathews, CA. (2016). The Role of Regional Conferences in Research Resident Career Development: The California Psychiatry Research Resident Retreat. Academic Psychiatry. 41(2): 272-277. PMCID: PMC5107358

Other

  1. Feldman WB, Besterman AD, Yu JP, Devido JJ, Bourgeois JA (2015). Persistent perceptual disturbances after lithium toxicity: A case report and discussion. Psychosomatics 56(3): 306-10. PMID: 25624181
  2. Besterman AD (2012). The ethics of genetic testing in psychiatry. American Medical Association Journal of Ethics. 14(6): 460-3. PMID: 23351260
  3. Al-Hashel J*, Besterman AD*, Wolfson C (2008) The Prevalence of Multiple Sclerosis in the Middle East. Neuroepidemiology 31: 129-137. PMID: 18716409 (*co-first author)
  4. Mortola JP and Besterman AD (2007) Gaseous metabolism of the chicken embryo and hatchling during post-hypoxic recovery. Respiratory Physiology and Neurobiology 156: 212-9. PMID: 17081809